The crash happened in Jackson Township, York County around 7:52 a.m. on Oct. 2, according to the Pennsylvania Department of Transportation.
The closure is between Big Mount, Labott, and Biesecker roads.
The highway remains closed in both directions as of 9:30 a.m.
This is a developing story. Check back here for updates.
Click here to follow Daily Voice Lower Paxton and receive free news updates.